| Player | School | Season | Points |
| Epiphanny Prince | Murry Bergtraum-NYC | 2005-06 | 113 |
| Nikki McCrimmon | West Side-NYC | 1989-90 | 80 |
| Wanda Camps | LaGuardia-NYC | 1993-94 | 77 |
| Felice Mann | Buffalo Burgard-6 | 1989-90 | 73 |
| Katesha Artis | South Shore-NYC | 1989-90 | 72 |
| Letitia Coates | Brandeis-NYC | 1990-91 | 65 |
| Felecia Griffin | Roosevelt-NYC | 1988-89 | 64 |
| Kristin McGarvey | Pearl River-1 | 1989-90 | 63 |
| Sara Pfeiffer | Olean | 2018-19 | 63 |
| Angie Paccione | Cornwall-9 | 1978-79 | 62 |
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| Tammi Reiss | Eldred-9 | 1987-88 | 62 |
| Valerie Wilmer | Gorton-1 | 1982-83 | 62 |
| Felice Mann | Buffalo Burgard-6 | 1989-90 | 61 |
| Dionne Burwell | Buffalo Arts-6 | 1992-93 | 61 |
| Saniya Chong | Ossining-1 | 2010-11 | 61 |
| Jennifer Mitchell | Hempstead-8 | 1972-73 | 60 |
| Jessie Kastaneda | Brooklyn Tech-NYC | 1992-93 | 60 |
| Eileen Emmert | Tappan Zee-1 | 1981-82 | 59 |
| Sue Wicks | Center Moriches-11 | 1983-84 | 59 |
| Tammi Reiss | Eldred-9 | 1987-88 | 59 |
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| Jessie Kastaneda | Brooklyn Tech-NYC | 1992-93 | 58 |
| Arella Guirantes | Bellport-11 | 2014-15 | 58 |
| Debbie Williams | Niagara LaSalle-6 | 1976-77 | 57 |
| Val Mosley | Grover Cleveland-6 | 1978-79 | 57 |
| Melissa Gaughan | Stillwater-2 | 1986 | 57 |
| Nikki McCrimmon | West Side-NYC | 1989-90 | 57 |
| Trish Raniewicz | Mercy-5 | 1998-99 | 57 |
| Val Mosley | Grover Cleveland-6 | 1977-78 | 56 |
| Julie Naedele | Lackawanna-6 | 1980-81 | 56 |
| Sue Wicks | Center Moriches-11 | 1982-83 | 56 |
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| Felice Mann | Buffalo Burgard-6 | 1989-90 | 56 |
| Anita Kaplan | Bethlehem-2 | 1990 | 56 |
| Katryna Gaither | Mount Vernon-1 | 1992-93 | 56 |
| Trish Raniewicz | Mercy-5 | 1998-99 | 56 |
| LuAnn Williamson | Ripley-6 | 1973-74 | 55 |
| Val Mosley | Grover Cleveland-6 | 1979-80 | 55 |
| Pam Jackson | Buffalo Traditional-6 | 1987-88 | 55 |
| LaToya Crumpton | Buffalo Hutch Tech-6 | 1992-93 | 55 |
| Saniya Chong | Ossining-1 | 2011-12 | 55 |
| Saniya Chong | Ossining-1 | 2011-12 | 55 |
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| Pam Lee | Alexnder-5 | 1979 | 54 |
| Denise McNeilly | Franklin-4 | 1985 | 54 |
| Val Mosley | Grover Cleveland-6 | 1979-80 | 54 |
| Patty Reynolds | Valley Stream South-8 | 1985-86 | 54 |
| Arlene Wilson | Buffalo South Park-6 | 1987-88 | 54 |
| Clare Guerriero | Curtis-NYC | 1987-88 | 54 |
| Katrina Springer | Broadalbin-2 | 1987 | 54 |
| Eva Kyriakopoulos | Long Island City-NYC | 1989-90 | 54 |
| Arlene Williams | Sheepshead Bay-NYC | 1992-93 | 54 |
| Dionne Burwell | Buffalo Arts-6 | 1992-93 | 54 |
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| Maddie Williams | Medina-6 | 2016-17 | 54 |
| Patty Reynolds | Valley Stream South-8 | 1984-85 | 53 |
| Jeanne Miller | Tuxedo-9 | 1985-86 | 53 |
| Missy Batchelor | St. Dominic-CHSAA | 1988 | 53 |
| Katryna Gaither | Mount Vernon-1 | 1991-92 | 53 |
| Jamie Burke | Prattsburg-5 | 1992-93 | 53 |
| Sheri Smith | Pulaski-3 | 1985-86 | 53 |
| Andra Espinoza-Hunter | Ossining-1 | 2016-17 | 53 |
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The NYSSWA compiles a list of players with 53 or more points in a game. This list was last updated Feb. 6, 2019.
